ZenZema^® FAQs

ZenZema is a science-first skin care brand formulated exclusively for eczema-prone (atopic dermatitis–prone) skin. Our products help relieve itch, protect dry and irritated skin, and support both the skin barrier and microbiome balance - so skin can feel calmer, more comfortable, and more resilient.

Eczema is a complex inflammatory skin condition with a variety of causes and triggers that are unique to patients living with AD. While other brands focus on sensitive skin and rely heavily on the benefits of colloidal oatmeal and barrier lipids, ZenZema specializes in ONLY eczema care with unique combinations of advanced precision ingredients for a more comprehensive approach. Our microbiome-conscious formulation prioritizes gentleness, long-term stability, and above all, lasting relief.

The skin is home to a thousand+ different types of bacteria. When our skin is healthy, there is a perfect balance of good bacteria. When eczema flares, the bad bacteria become more dominant and can damage the skin barrier, drive troublesome itch, redness, and excessive dryness. Restoring balance to the skin microbiome is essential in eczema care.

Our hero Eczema Itch Spray features our patented Ecz-Rx technology, a precision enzyme technology developed specifically for eczema-prone skin to address microbiome imbalance and the troubling symptoms it can cause. Our Eczema Itch Spray is the perfect booster to your eczema treatment routine.

Ecz-Rx is inspired by nature: specifically, how the skin’s microbiome stays naturally in balance. When skin is healthy, the microbiome is diverse and balanced.

After evaluating hundreds of enzyme candidates, Ecz-Rx was selected for its precision efficacy, gentleness, and real-world formulation stability. It is designed for everyday use without refrigeration.

Flareguard^® Complex is ZenZema’s proprietary blend of L-Histidine, colloidal oatmeal, licorice root, chamomile, ceramides, and microbiome-supporting postbiotics, found in our Soothing Cream and Daily Cleanser. Together, these ingredients help calm visible irritation, strengthen the skin barrier, and support a healthy skin microbiome—three factors that are critical for eczema-prone skin. The complex is designed to address a common underlying challenge in eczema: weakened barrier function often linked to reduced filaggrin, a key protein that helps skin stay strong and hydrated. L-Histidine helps support filaggrin formation, while colloidal oatmeal, ceramides, and soothing botanicals help lock in moisture, reduce visible redness and itch, and reinforce the skin’s protective barrier. Microbiome-supporting postbiotics help maintain a balanced skin ecosystem, promoting calmer, more resilient skin over time.

Our first available product is the ZenZema^® Eczema Itch Spray. Additional products including Eczema Soothing Cream, Eczema Daily Cleanser, and Daily Probiotic are launching soon.

All products are developed for eczema-prone and atopic dermatitis-prone skin.

Eczema-prone/atopic dermatitis-prone skin is often associated with barrier disruption and microbial imbalance. ZenZema's formulations are designed to support barrier function while maintaining a balanced microbial environment on the skin.

All topical ZenZema^® products are MyMicrobiome certified.

Yes. All ZenZema topical products are formulated for skin sensitivities associated with eczema-prone and atopic dermatitis-prone skin. They are dermatologist and pediatrician approved, National Eczema Association Seal Accepted, MyMicrobiome Certified, and tested extensively on sensitive skin.

ZenZema Eczema Itch Spray is tested and safe for use for adults and children 3 months and older.

Many OTC skin protectants for eczema and atopic dermatitis are commonly used during pregnancy. However, if you are pregnant or breastfeeding, consult your healthcare provider before introducing new skincare products.

Our products can be used as needed, especially when skin feels itchy, dry, or tight. ZenZema Eczema Itch Spray should be used twice daily on clean, dry skin. It can also be used for spot relief throughout the day as needed.

Many people use ZenZema on facial eczema. Avoid direct contact with eyes. When using near the eye area, apply carefully and patch test first.

ZenZema products are designed to be easily incorporated into eczema and atopic dermatitis care routines including moisturizers, steroid creams, and prescription treatments. Consult your healthcare provider for personalized guidance, especially for infants or severe cases.

Many individuals experience soothing hydration quickly after application. In ZenZema Eczema Itch Spray studies, 89% of users reported itch relief within the first 12 hours. Unlike some treatments that may initially cause irritation, this product typically provides immediate comfort, lasting relief, and steady improvement. Many individuals experience improved sleep, gaining itch relief through the night.

No. ZenZema Eczema Itch Spray has been developed for the unique itch associated with eczema. Please ask your dermatologist about options for these other conditions.

There is currently no cure for eczema or atopic dermatitis. ZenZema products are designed to help relieve itch and protect dry, irritated skin as part of a comprehensive eczema management routine. When used as directed, individuals have experienced significant relief from itch and seen visible results.

Common triggers include dry weather, stress, sweat, irritants such as fragrance or harsh soaps, allergens, temperature changes, and scratching. Identifying personal triggers and maintaining daily barrier care can help support more comfortable skin.

ZenZema products are currently available here on ZenZema.com and on Amazon.

Yes. All ZenZema topical products are NEA Accepted.